Table 7. Surrogate parameters for insulin resistance and insulin sensitivity.

	C57Bl6	alb-SREBP-1c
blood glucose [mmol/l]	7.82±0.99	11.01±1.39**
insulin [ng/ml]	0.95±0.53	3.56±1.11**
HOMA-IR	0.31±0.14	1,78±0.71**
QUICKI	0.47±0.04	0.34±0.02**

Data are mean ± SD (n = 20). T-test C57Bl6 vs. alb-SREBP-1c: **p<0.01.

Surrogate indices were calculated from fasting blood glucose and plasma insulin concentrations as follows: QUICKI = 1/[log(I0)+log(G0)], where I0 is fasting insulin (µU/ml) and G0 is fasting glucose (mg/dl); and HOMA-IR = (G0 * I0)/22.5, with glucose expressed as mmol/l and insulin expressed as µU/ml.). Data were calculated from all mice investigated. Students t-test was performed to determine significance (C57Bl6 vs. alb-SREBP-1c mice: **p<0.01).