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. 2012 Feb 21;7(2):e32128. doi: 10.1371/journal.pone.0032128

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Shi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A penetrating corneal wound model was created with Wistar rats and inhibition of JNK activation by subconjunctival injection of SP600125 daily post-wounding. (A) HE stained histological sections showed that corneal epithelial healing was almost complete at 3 d in both groups. Subconjunctival injection of SP600125 after injury daily markedly improved the architecture of cornea and reduced scarring and did not have a significant impact on wound stroma healing at 14 d (B), 21 d (C). n = 4 rat in each group, Bars: 40 µm.