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. 2012 Feb 21;7(2):e32191. doi: 10.1371/journal.pone.0032191

Figure 3. Inhibition of IGFR1, but not IGFR2, inhibits vasculogenesis in differentiating embryoid bodies.

Figure 3

A) Tie-2 expression in is decreased in EB treated with IGFR1 neutralizing antibody (nAb IGFR1). Tie-2 expression (FITC), DAPI nuclear counterstain. B) IGFR1 neutralizing antibody treatment (Antibody/Ab) significantly reduces levels of endothelial markers. C) IGFR2 neutralizing antibody treatment had no significant effects on levels of VEGFR2 or Tie-2. * denotes P<0.05 to control, Rn denotes normalized reporter.