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. 2012 Feb 21;7(2):e32195. doi: 10.1371/journal.pone.0032195

Figure 9. mTOR is required for resveratrol-inhibited expression of NF-κB/RelA protein and mRNA induced by LPS in BV-2 cells.

Figure 9

Panel A shows the immunofluorenscence images for protein expression of NF-κB/RelA and Panel B shows the corresponding mRNA data. The relative mRNA level was quantified by scanning densitometry and normalized to β-actin mRNA. Note the up-regulated protein and mRNA expression of NF-κB/RelA by LPS is suppressed by different concentrations of resveratrol; however, in cells pretreated with mTOR inhibitor rapamycin, the suppressive effect of resveratrol is abrogated. The values shown are mean ± SEM of data from three independent experiments. #Significant compared with control alone, p<0.05. *Significant compared with LPS alone, p<0.05. ▵Significant compared with resveratrol+LPS, p<0.05.