Figure 5. Association between affinity (measured as k^d) and protection from clinical malaria.

Affinity versus protection for the individuals in the Tanzanian population that were P. falciparum positive (n = 77). Individuals with high affinity had lower risk of developing malaria during follow-up (No malaria = did not get malaria within 40 weeks, Malaria = Experienced a clinical episode of malaria during follow up). Fc27 and 3D7 indicates the recombinant MSP2 proteins used in the SPR assay. (Box plots representations as in Figure 2.)