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Proposed model for PI3K-mediated regulation of erythroblast enucleation. The reorientation from a radial microtubule array to an asymmetric array results in localized activation of PI3K and thereby promotes asymmetric actin assembly. Enucleation is triggered and continued by a pressure generated by contractions of cytoplasmic actomyosin (large arrow) and is probably completed by contractions of concentrated actomyosin at the bleb neck (small arrows).
