Table I.
Selected clinical data from the cyclosporine A treated and healthy children
| Data | Study group | Controls |
|---|---|---|
| Number of patients | 19 | 16 |
| Male/female | 11/8 | 10/6 |
| Age [years] | 10.8 ±4.4 | 11.7 ±3.8 |
| BMI [kg/m2] | 20.9 ±5.5 | 18.5 ±2.6 |
| Systolic blood pressure [mmHg] | 118 ±11* | 112 ±3 |
| Diastolic blood pressure [mmHg] | 75 ±6* | 71 ±3 |
| NS treatment [months] | 75.6 ±49.2 | – |
| eGFR [ml/min/1.73 m BSA] | 128 | 135 |
| CsA treatment [months] | 44.5 ±27.6 | – |
| Mean CsA [ng/ml] | 70.9 ±47.0 | – |
| Haemoglobin [g/l] | 133 ±9 | 136 ±11 |
| Albumin [g/l] | 33 ±4 | 35 ±5 |
| Response to steroid therapy: | ||
| • steroid dependency | 18 | – |
| • steroid resistance | 1 | |
| Histology at onset of NS: | ||
| • MCD | 18 | – |
| • FSGS | 1 | |
| Nephrotoxicity on renal biopsy [patients] | 2 | – |
| Hypertension [patients] | 5* | 0* |
* significantly different vs. controls p < 0.05