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. 2011 Dec 8;21(6):1336–1349. doi: 10.1093/hmg/ddr572

Figure 5.

Figure 5.

Mutations causing steric clashes in the ankyrin-repeat region. (A–D) Effect of the Ala182Val, Val192Leu, Gln280Leu and Ala305Thr mutations. In the wild-type (A), Ala182 and Val192 form tight interactions with Thr178 and Leu204, respectively. In the wild-type (C), Gln280 and Ala305 form tight interactions with Asp309 and His341, respectively. The longer side chains present in all mutants (B, D) lead to clashes with the neighboring residues (marked by red arrows) potentially resulting in decreased protein stability.