Table 1.

The component models of the glucose homeostasis system.

model name	biology	source	units	computational language	inputs	outputs to
G-protein model A	glucagon receptor βγ sub-units, desensitization, PLC	[34,32,33]	M,s	Mathematica	G,B	B
calcium model B	IP3, calcium oscillations	[36]	M,s	XPPAUT	B	B,F
cAMP model C	glucagon receptor α sub-unit, cAMP, PKA	ab initio	arbitrary, h	Mathematica	G	F
insulin model D	insulin receptor, PIP, GSK	ab initio	arbitrary, min	XPPAUT	G	F
blood model E	metabolic demand, transmembrane glucose transport	ab initio	M,s	XPPAUT	F	F,G
glycogen model F	control of glycogen phosphorylase and synthase	[12,15,8,9]	M blood equiv.	XPPAUT	B,C,D,E	F
pancreas model G	glucagon and insulin production	ab initio	arbitrary, min	Mathematica	F	A,C,D