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Citrate synthase (CS) enzyme activity (left Y-axis) and mitochondrial DNA content (right Y-axis) in heart muscle samples from wild type mice (WT) and dominant negative AMPKα2 (AMPK KD) mice. Young (Y: 19–22 weeks) and old (O: 76–91 weeks) mice were studied in both groups. *Different from age matched wild type (P < 0.05).
