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. 2012 Feb 16;7:827–834. doi: 10.2147/IJN.S27803

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© 2012 Hao et al, publisher and licensee Dove Medical Press Ltd.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

PMC Copyright notice

Coexpression of human SCCA1 and FTL in mouse liver enhances HBV replication. Plasmids pcDNA3.1 (column 1 in A; a in B), pcDNA3.1-SCCA1 (column 2 in A; b in B), pcDNA3.1-FTL (column 3 in A; c in B), or both of pcDNA3.1-SCCA1 and pcDNA3.1-FTL (column 4 in A; d in B) were introduced into mouse liver via hydrodynamic injection through tail vein. (A) Serum level of HBsAg determined 24 hours post virus challenge. (B) Immunohistochemical staining of HBcAg 48 hours post virus challenge.

Abbreviations: SCCA1, squamous cell carcinoma antigen 1; FTL, ferritin light chain; HBV, hepatitis B virus; HBsAg, hepatitis B virus surface protein antigens; HBcAg, hepatitis B virus core protein antigens.