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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: J Immunol. 2011 Aug 29;187(7):3738–3750. doi: 10.4049/jimmunol.1003783

Table III. Efficacy of the vaccine mixture against P. yoelii sporozoite challenge.

BALB/c mice were immunized with the regimes described in Table I and challenged i.v. with sporozoites at the indicated time-points. Parasitemia was monitored as described.

Immunization Regime No. survived /
No. challenged
(% survival)		 No. sterilely
protected /
No. challenged
(% survival)		 Geometric mean
(range) peak
parasitemia of
surviving mice
A) 1000 sporozoites, 2 weeks post boost
MSP1 + CSP 5/6 (83%) 1/6 (16%) 4.62% (0 – 28%)
MSP1 + Control 6/6 (100%) 1/6 (16%) 1.80% (0 – 7.9%)
CSP + Control 4/6 (66%) 4/6 (66%) N/A
Naïve unimmunized 0/6 (0%) 0/6 (0%) N/A
B) 50 sporozoites, 10 weeks post boost
MSP1 + CSP 5/6 (83%) 2/6 (33%) 4.53% (0 – 11.8%)
MSP1 + Control 6/6 (100%) 1/6 (16%) 0.20% (0 – 17.6%)
CSP + Control 3/6 (50%) 3/6 (50%) N/A
Naïve unimmunized 0/6 (0%) 0/6 (0%) N/A