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View full-text article in PMC

. 2011 Dec 8;9:212. doi: 10.1186/1479-5876-9-212

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Copyright ©2011 Currier et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of epitope requirements for vaccine coverage in multiple-epitope hit models. Comparisons of 1-, 2- and 3-exact hit epitope requirement models are shown for a mono-valent product (MVA-CMDR Gag and Env inserts) assessed against a dataset of homologous subtype (CRF01_AE) derived sequences (88 Gag sequences, Panel A; 112 Env sequences, Panel B). For contrast a tetra-valent formulation of the products (ACDE) assessed against the entire HIV-1 group M Gag (Panel C) and group M Env (Panel D) datasets is also shown. In all graphs the 1-hit model is represented by the blue line and symbols, the 2-hit model is the green line and symbols and the 3-hit model is the red line and symbols. For reference, the 90% coverage point for each dataset is again denoted by a dotted line on each graph.