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Comparison of Env and Gag epitope coverage requirements. Shown is the ratio of Env:Gag epitope requirements to reach 95%, 90% or 75% coverage of the global HIV-1 group M datasets for any given formulation of the four natural sequence-based products. Regardless of the valency of the vaccine product Env consistently requires approximately two-fold more epitopes to be generated than Gag to reach any given level of coverage.
