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Resveratrol suppresses ERK and mTOR signaling in sensory neurons in a concentration-dependent manner. Treatment of TG neurons with resveratrol (10, 30, and 100 μM) for 1 h induces a concentration-dependent increase in phosphorylation of AMPK (A). Resveratrol treatment significantly decreases the phosphorylation of ERK (B), eIF4E (C), AKT (D), mTOR (E), TSC2 (F) 4EBP (G) and rS6p (I) but increases eIF4G phosphorylation (H).
