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. 2012 Feb 22;7(2):e32078. doi: 10.1371/journal.pone.0032078

Figure 2. Anti-Gβγ blocking peptide prevents in vivo antigen-induced airway hyperresponsiveness in OVA-sensitized rabbits.

Figure 2

Relative to OVA-challenged control (non-sensitized; n = 4) rabbits, Rrs responses to MCh are significantly increased at 24 hr following antigen challenge in OVA-sensitized rabbits (n = 4). This heightened bronchoconstrictor responsiveness to MCh is suppressed in OVA-sensitized rabbits that are treated either with inhaled anti-Gβγ peptide (1 mg/Kg; n- = 4) or budesonide (0.5 mg/Kg; n = 3) prior to antigen challenge. Data are mean ± SE values. ANOVA used for multiple comparisons of mean Rrs values. *p<0.05; **p<0.01. Note: a significant difference is also detected when using the nonparametric Kruskal-Wallis test with Dunn's post-test to compare the medians of the Rrs-max responses in the control vs. non-pretreated OVA sensitized rabbits (p<0.05), whereas no significant difference is detected between the control vs. OVA-sensitized animals that are pretreated with the anti-Gβγ blocking peptide.