Figure 3. Anti-Gβγ blocking peptide suppresses pulmonary inflammation in OVA-sensitized rabbits.

Relative to controls (A), lungs isolated from antigen-challenged OVA-sensitized rabbits exhibit diffusely scattered patchy foci of inflammatory cell infiltration, including in peribronchial, perivascular, and parenchymal regions (B). Contrasting the lack of effect of pretreatment with MPS alone (C), inflammation is suppressed to a similar extent in antigen-challenged OVA-sensitized rabbits that were pretreated either with inhaled budesonide (D) or anti-Gβγ peptide (E), whereas pretreatment with gallein has relatively little anti-inflammatory effect (F). Representative photomicrographs (mag. ×100) are from 4 µM sections of H&E stained lung sections.