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. 2012 Feb 22;7(2):e32078. doi: 10.1371/journal.pone.0032078

Figure 5. Proinflammatory cellular and cytokine responses in antigen-challenged OVA-sensitized rabbits are suppressed by anti-Gβγ blocking peptide.

Figure 5

Relative to controls, total inflammatory cell count (A) and neutrophil/macrophage cellular ratio (B), are significantly increased in BALF samples from antigen-challenged OVA-sensitized rabbits. Correspondingly, BALF levels of INF-γ are significantly reduced whereas IL-13 levels are increased in OVA-sensitized+challenged animals. These proinflammatory indices are suppressed in BALF from sensitized rabbits that are treated with inhaled anti-Gβγ peptide prior to OVA challenge. Data are represented by bar plots depicting median and range values. Statistical comparisons are made using the Kruskal-Wallis test. *p<0.05 based on Dunn's post-test.