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. 2012 Feb 22;7(2):e31522. doi: 10.1371/journal.pone.0031522

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Performance on the accelerating rotarod was measured in Aldh1a1 ^−/−×Aldh2 ^−/− double knockout mice and age-matched wild type controls (A) before and (B) after L-DOPA treatment. Stride length was measured in Aldh1a1 ^−/−×Aldh2 ^−/− double knockout mice and age-matched wild type controls (C) before and (D) after L-DOPA treatment. Measurement of stride length after elimination of L-DOPA (E) was performed 7 days after L-DOPA injection. Data in all panels are expressed as mean ± SEM of the following number of animals in each age group: young (wt = 5, ko = 6), middle-aged (wt = 5, ko = 13) and old (wt = 13, ko = 16) male mice. Asterisks above bars indicate significant difference between age-matched wt and ko groups. Asterisks above lines indicate significant difference between indicated means. *P<0.05; **P<0.01; ***P<0.001.