Figure 5. Effect of age and genotype on Y maze performance.

(A) Total arm entries, (B) novel arm entries and (C) percent of arm alternations were measured in Aldh1a1 ^−/−×Aldh2 ^−/− double knockout mice and age-matched wild type controls. Data are expressed as mean ± SEM of young (wt = 5, ko = 7), middle-aged (wt = 5, ko = 13) and old (wt = 13, ko = 13) male mice. Asterisks above bars indicate significant difference between age-matched wt and ko groups. Asterisks above lines indicate significant difference between indicated means. *P<0.05; **P<0.01; ***P<0.001.