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. 2012 Feb 22;7(2):e31522. doi: 10.1371/journal.pone.0031522

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The level of serotonin (A) and its metabolite, 5-HIAA (B) were measured in Aldh1a1 ^−/−×Aldh2 ^−/− mice and age-matched wild type controls. Pathways by which 5HT is metabolized to its metabolites are shown in (C). Data are expressed as the mean ± SEM of the following number of wild-type and knockout mice in each age group: young (wt = 13, ko = 11), middle-aged (wt = 16, ko = 20) and old (wt = 23, ko = 32) male mice. *P<0.05, significantly different from age-matched wild-type control group. **P<0.01, significantly different from age-matched wild-type control group.