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. 2012 Feb 22;7(2):e31522. doi: 10.1371/journal.pone.0031522

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A–F) Representative coronal sections from Aldh1a1 ^−/−×Aldh2 ^−/− mice and age-matched wild type controls showing regions of substantia nigra pars compacta (SNpc) selected for TH+ cell counts. Quantification data of (G) TH+ neurons, (H) Nissl cells, and (I) TH+ cell volume are expressed as the mean ± SEM of the following number of mice in each group: young (wt = 4, ko = 3), middle-aged (wt = 5, ko = 5) and old (wt = 5, ko = 9) male mice. *P<0.05, significantly different from age-matched wild-type control group.