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. 2012 Feb 22;7(2):e31686. doi: 10.1371/journal.pone.0031686

Figure 2. GUCY2C-deficiency increases susceptibility to DSS-induced colitis.

Figure 2

Gucy2c+/+ and Gucy2c−/− male mice were administered 3% DSS in drinking water for 7 d to disrupt the epithelial barrier and induce colitis. Severity of colitis was analyzed by (A) body weight (n = 11) and (B) survival (n≥11). (C) Colon length was measured from the colocecal junction to the anal verge on day 12 (5 d post-DSS exposure) to quantify chronic inflammation. (D) Histological sections obtained from jejunum and distal colon on day 12 were stained with H&E and scored for epithelial and mesenchymal inflammation. Each point represents one mouse. (E) Representative H&E colon sections (20×). Data are mean ± SD (in C) and SEM (in D) obtained from one of three independent experiments. **, p<0.01, ***, p<0.001.