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. 2012 Feb 22;7(2):e31686. doi: 10.1371/journal.pone.0031686

Figure 5. GUCY2C modulates systemic genotoxicity and tumorigenesis.

Figure 5

(A) Eliminating GUCY2C increases basal DNA oxidation in leukocytes. Each point represents one mouse. (B) Oral ST supplementation decreases DSS-induced hepatic genotoxicity. Gucy2c+/+ mice were preconditioned with oral ST for 6 d, and then treated with 3.5% DSS for 7 d, followed by quantification of DNA oxidation in liver on days 10 (n≥5) and 13 (n≥2; 3 and 6 d post-DSS exposure). Data represent mean ± SD. (C) Gucy2c−/− mice exhibited a higher incidence of spontaneous tumors comparing with age-matched 2-year-old Gucy2c+/+ mice (n≥14, p = 0.02). (D) The carcinogen AOM induced hepatoma in Gucy2c−/−, but not Gucy2c+/+, mice (n≥10, p = 0.04). C and D are analyzed by two-sided Fisher's exact test. *, p<0.05.