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Suppression of cancer stemness p53-p21 regulation in recurrent tumors. Primary disease is characterised by the expression of p53-regulating stemness signature genes Sox4 and Sdsl, which is continued and enhanced with Dusp26 expression in the recurrency. In contrast, p21 regulating stemness signature genes Pak6 and Cask are expressed in primary disease and suppressed in recurrency. This process is paralleled by recruitment of stemness signature miRNAs by recurrent disease.
