Figure 3. Modulation of sympathetic vasoconstriction in rat hindlimb muscles.

A, sympathetic stimulation evoked similar decreases in femoral vascular conductance in resting hindlimbs (filled symbols) of vehicle- and NTG-treated rats. These vasoconstrictor responses were attenuated during contraction in both groups (open symbols), but the degree of attenuation was less in the NTG-treated rats. B, in these same rats, infusion of tempol selectively attenuated sympathetic vasoconstriction only in the contracting hindlimbs of the NTG-treated rats. Vehicle and NTG, n = 9 per group. *P < 0.05 vs. rest; ^†P < 0.05 vs. vehicle.