Table 1.
NMR Data for Pre-sclerotiotide F (3) and Sclerotiotide F (4) a
| Pre-sclerotiotide (3) |
Sclerotiotide F (4) |
|||
|---|---|---|---|---|
| position | δH, mult. (J in Hz) | δC, type | δH, mult. (J in Hz) | δC, type |
| 1 | 173.1, C | 172.6, C | ||
| 2 | 5.05, ddd (7.2, 7.2, 0.6) | 49.7, CH | 5.00, ddd (7.2, 6.6, 1.2) | 49.8, CH |
| 3 | 2.37, m, 1.71, m | 28.2, CH2 | 2.39, m, 1.69, m | 28.3, CH2 |
| 4 | 1.76, m, 1.58, m | 21.8, CH2 | 1.70, m, 1.58, m | 21.7, CH2 |
| 5 | 3.48, m, 2.95, m | 39.9, CH2 | 3.34, m, 3.12, m | 39.7, CH2 |
| 6 | 6.44, brd (6.0) | 5.80, t (6.0) | ||
| 7 | 172.5, C | 171.3, C | ||
| 8 | 4.19, dq (9.0, 7.2) | 51.7, CH | 4.63, q (7.2) | 55.3, CH |
| 9 | 1.45, d (7.2) | 19.3, CH3 | 1.52, d (7.2) | 16.7, CH3 |
| 11 | 170.8, C | 169.1, C | ||
| 12 | 4.98, d (10.2) | 58.4, CH | 5.11, d (10.2) | 58.7, CH |
| 13 | 2.39, m | 26.3, CH | 2.43, m | 26.9, CH |
| 14 | 0.75, d (6.6) | 17.8, CH3 | 0.75, d (7.2) | 17.9, CH3 |
| 15 | 0.96, d (6.0) | 19.7, CH3 | 0.92, d (6.6) | 19.8, CH3 |
| 17 | 7.20, d (9.0) | 3.05, s | 29.8, CH3 | |
| 18 | 3.00, s | 30.3, CH3 | 2.98, s | 30.3, CH3 |
| 19 | 7.04, d (7.2) | 6.89, d (6.6) | ||
| 20 | 163.4, C | 163.2, C | ||
| 21 | 6.40, d (15.0) | 132.0, CH | 6.34, d (15.0) | 131.8, CH |
| 22 | 7.38, dd (15.0, 11.4) | 137.5, CH | 7.38, dd (15.0, 11.4) | 137.7, CH |
| 23 | 7.13, dd (15.0, 11.4) | 147.5, CH | 7.15, dd (15.0, 11.4) | 147.4, CH |
| 24 | 6.41, dd (15.0, 8.4) | 136.5, CH | 6.41, dd (15.0, 7.8) | 136.6, CH |
| 25 | 9.65, d (8.4) | 193.0, CH | 9.96, d (7.8) | 193.0, CH |
a
Spectra were recorded in CDCl3 at 600 and 150 MHz for 1H and 13C NMR, respectively (TMS as internal standard).