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Binding events at the domain I/II interface affect several His Hε1 resonances. (A) Interface with the disrupted Zn-binding site A (magenta) and interdomain His residues likely to be affected by fatty acid binding in site FA2. The 11 resolved carbons of Myr2 in PDB entry 1bj5 are shown as pink spheres. (B) Effects of 1 molar equiv of Zn and 5 molar equiv of OCT on His Hε1 resonances. Peaks 1 and 4 are assigned to His67 and His247;14 full titration data are shown in Figure S3.
