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. 2012 Feb 22;7(2):e31456. doi: 10.1371/journal.pone.0031456

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Song et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Percentages of TrxR, GR and Grx activities inhibited by different doses of auranofin with DTNB, GSSG or HED as substrate. (B) Inhibition constant () values of auranofin on recombinant SjTGR in the TrxR assay. The straight lines were fitted on the basis of the reciprocal of concentration of substrate and initial velocity. The concentrations of auranofin were 0 nM, 5 nM, 10 nM and 15 nM, and DTNB ranged from 60 to 1,000 µM. (C) Inhibition constant () values of auranofin on SjTGR in the GR activity assay. The straight lines were fitted on the basis of the reciprocal of concentration of substrate and initial velocity. The concentrations of auranofin were 0 nM, 5 nM, 10 nM and 20 nM, and GSSG ranged from 10 to 100 µM.

Inline graphic — (A) Percentages of TrxR, GR and Grx activities inhibited by different doses of auranofin with DTNB, GSSG or HED as substrate. (B) Inhibition constant () values of auranofin on recombinant SjTGR in the TrxR assay. The straight lines were fitted on the basis of the reciprocal of concentration of substrate and initial velocity. The concentrations of auranofin were 0 nM, 5 nM, 10 nM and 15 nM, and DTNB ranged from 60 to 1,000 µM. (C) Inhibition constant () values of auranofin on SjTGR in the GR activity assay. The straight lines were fitted on the basis of the reciprocal of concentration of substrate and initial velocity. The concentrations of auranofin were 0 nM, 5 nM, 10 nM and 20 nM, and GSSG ranged from 10 to 100 µM.