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. 2012 Feb 22;7(2):e31456. doi: 10.1371/journal.pone.0031456

Figure 7. Inhibition of S. japonicum adult worms by auranofin in vitro.

Figure 7

(A) Effects of auranofin (AUF 1, 5, 10, 20, 30 µg/ml) on TrxR and GR activities of adult worms after 3 h of treatment. Worms were mock treated in the control groups (RPMI 1640 and 1.2% DMSO). Worms were treated with 30 µg/ml of praziquantel in the PZQ 30 µg/ml group. (B) Inhibition of auranofin on TrxR activity of adult worms over time. Worms were treated with 5 and 10 µg/ml of auranofin, and the TrxR activities of worm homogenates were tested after 0, 1, 3 and 6 h. (C) Inhibition of auranofin on GR activity of adult worms over time. Worms were treated with 5 and 10 µg/ml of auranofin, and the GR activities of worm homogenates were tested after 0, 1, 3 and 6 h.