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. 2012 Feb 22;7(2):e31951. doi: 10.1371/journal.pone.0031951

Figure 4. The histidine decarboxylase gene cluster contributed to the TNF-inhibitory phenotype of L. reuteri 6475.

Figure 4

The histidine decarboxylase gene cluster consists of three genes, hdcP (RPRB3004), hdcA (RPRB3005), and hdcB (RPRB3006). The organization of the cluster is depicted above the bar graph. Inactivation by targeted mutagenesis in any one of these genes resulted in a partial loss (approximately 40%) of TNF suppression by L. reuteri 6475. Results represent the mean ± SD (n = 9), *p value<0.05 compared to medium control, #p value<0.05 compared to L. reuteri 6475.