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. 2012 Feb 22;7(2):e31951. doi: 10.1371/journal.pone.0031951

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Thomas et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Immunoblot studies were performed to determine the effect of histamine on activation of the ERK signaling pathway. ERK was activated by phosphorylation on Thr202/Tyr204 (P-ERK). Treatment of TLR-stimulated THP-1 cells with L. reuteri 6475, histamine, or U0126 suppressed activation of ERK1/2, an effect that was significantly blocked in the presence of ranitidine. The β-actin antibody served as the protein loading control.