Table 5. Comparison of divergence times (in years before 2008) for main subtypes in the Tick-borne encephalitis virus species between the present study estimates and dating derived from rates of non-synonymous substitution calculated with a strict molecular clock [38].

Divergence event	Present study estimates	Estimates in reference [38]
LI/MA54 & LI/31 (node F)	870 [670–1087]	273 [218–328]
LIV & SSEV (node M)	1116 [896–1380]	268 [214–322]
LIV & W-TBEV (node G)	2027 [1563–2565]	431 [364–498]
LIV & TSEV (node H)	2426 [1841–3065]	449 [379–519]

Node designations refer to Figure 5. Confidence intervals are indicated between brackets.