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. 2012 Feb 22;7(2):e32103. doi: 10.1371/journal.pone.0032103

Table 1. First and second line drug resistant frequency among 1893 clinical Mycobacterium tuberculosis isolates, June 2009–June 2011, Xinjiang Uygur Autonomous Region, China.

Drugs No. isolates Rate, % (95% CI)
Overall first-line drug resistance 1117 59.0(56.8–61.2)
INH 683 36.1(33.9–38.2)
RFP 368 19.4(17.7–21.2)
SM 685 36.2(34.0–38.4)
EMB 332 17.5(15.8–19.3)
Overall MDR 249 13.2(11.6–14.7)
INH+RFP 73 3.9(3.0–4.7)
INH+RFP+SM 111 5.9(4.8–6.9)
INH+RFP+EMB 23 1.2(0.7–1.7)
INH+RFP+SM+EMB 42 2.2(1.6–2.9)
Overall second-line drug resistance 616 32.5(30.4–34.7)
FQ 477 25.2(23.2–27.2)
AMK 113 6.0(5.0–7.0)
CPM 121 6.4(5.3–7.5)
KAN 169 8.9(7.6–10.2)
PTA 85 4.5(3.6–5.4)
Overall pre-XDR 77 30.9(25.1–36.7)
FQ 65 26.1(20.6–31.6)
AMK 6 2.4(0.5–4.3)
CPM 2 0.8*
KAN 4 1.6*
Overall XDR 31 12.5(8.3–16.6)
FQ+AMK 7 2.8(0.7–4.9)
FQ+KNA 10 4.0(1.6–6.5)
FQ+AMK+CMP 1 0.4*
FQ+AMK+KNA 1 0.4*
FQ+CMP+KNA 1 0.4*
FQ+AMK+CMP+KNA 4 1.6*
FQ+AMK(2)/CPM(1)/KNA+PTA 3 1.2*
FQ+AMK+CMP/KNA+PTA 3 1.2*
FQ+AMK+CMP+KNA+PTA 1 0.4*

CI, confidence interval; INH, isoniazid; RFP, rifampin, SM, streptomycin, EMB, ethambutol; MDR, multidrug-resistant; FQ, fluoroquinolines (specifically ciprofloxacin, levofloxacin and ciprofloxacin.); AMK, amikacin; CPM, capreomycin; PTA: prothionamid, KAN: kanamycin.

*

95%CI was not determined.