Table 4. Pervasively rhythmic clock-controlled genes associated with BD-spectrum illnesses.
Clock ControlledGene | Disorder | GWAS p-value (best) | Li FDR p-value |
ACSL1 | ADHD | 6.91E-04 | |
ANP32A | MDD | 6.51E-04 | 0.25 |
BTF3L4 | SCH | 2.46E-04 | |
CAPRIN1 | BD | 5.34E-05 | |
CEBPB | MDD | 3.59E-04 | |
COL4A1 | SCH | 5.99E-04 | 0.24 |
COL4A2 | SCH | 5.99E-04 | |
COL6A1 | ADHD | 5.38E-04 | |
DUSP1 | BD | 5.36E-04 | 0.18 |
ELOVL5 | SCH | 6.44E-04 | 0.21 |
FOXP1 | BD+MDD+SCH | 3.43E-05 | 0.20 |
GLUL | MDD | 9.81E-04 | 4.79E-03 |
H1F0 | ADHD | 1.85E-04 | 0.25 |
H3F3B | SCH | 9.07E-05 | 0.02 |
HERPUD1 | MDD | 4.11E-04 | 0.02 |
HIST1H1C | SCH | 3.71E-04 | 2.90E-03 |
HIST1H2BC | SCH | 3.49E-04 | 0.21 |
HMGB3 | BD | 4.05E-04 | |
MAPRE1 | MDD+SCH | 1.12E-04 | 0.04 |
MCL1 | ADHD | 8.23E-04 | 0.09 |
NAMPT | BD+MDD | 6.46E-04 | |
NEDD4L | ADHD | 9.34E-05 | 0.17 |
PDIA6 | ADHD | 7.63E-04 | |
PFKFB3 | BD+MDD | 7.67E-05 | 0.15 |
PSMD11 | MDD+SCH | 4.28E-04 | 0.02 |
SASH1 | MDD | 8.16E-04 | 0.08 |
SFRS5 | BD | 9.66E-04 | 0.03 |
SFRS6 | ADHD+SCH | 1.20E-04 | |
SLC4A4 | BD | 2.13E-05 | 0.07 |
TIMP3 | BD | 7.16E-05 | 0.02 |
TUBA1B | BD | 2.38E-04 | |
UBC | MDD | 1.34E-04 | |
ZNF706 | BD | 3.72E-05 |
Data shown include 1) any gene associations with BD or BD-related illnesses as determined by SLEP search (left), 2) the best GWA p-value for a proximal SNP obtained from SLEP (middle), 3) an FDR-corrected p-value for any gene that was determined to be nominally lithium-responsive (right). Bold indicates significance after FDR correction.