Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Mean menstrual blood loss
Systematic review	153 women 5 RCTs in this analysis	Mean menstrual blood loss with tranexamic acid (250–500 mg 4 times daily during menstruation) with placebo Absolute results reported graphically	WMD –52 mL Other results and significance presented graphically	Effect size not calculated	tranexamic acid
Systematic review	Women with menorrhagia (number of women not reported) 2 RCTs in this analysis	Mean menstrual blood loss with tranexamic acid (both active forms of drug) with placebo Absolute results not reported	WMD –94 mL 95% CI –151 mL to –37 mL	Effect size not calculated	tranexamic acid
RCT	187 women with mean menstrual blood loss 80mL or more per cycle	Change in mean menstrual blood loss –69.6 mL with tranexamic acid –12.6 mL with placebo	P <0.001	Effect size not calculated	tranexamic acid