Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Menstrual blood loss
Systematic review	46 women Data from 1 RCT	Mean menstrual blood loss with tranexamic acid with norethisterone Absolute results not reported	WMD –111 mL 95% CI –179 mL to –44 mL	Effect size not calculated	tranexamic acid
RCT	100 women with dysfunctional uterine bleeding	Change in menstrual blood loss from baseline (measured on pictorial blood loss assessment [PBAC] chart scale) 3 months From 356.9 to 141.6 (60.3% reduction) with tranexamic acid (500 mg four times daily for 5 days during menstruation) From 370.9 to 156.6 (57.7% reduction) with medroxyprogesterone acetate (10 mg twice daily from day 5 to day 25 of the cycle)	P <0.005 for difference between pre- and post-treatment PBAC rating for each treatment The RCT also found that both treatments improved menstrual blood loss from baseline	Effect size not calculated