Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Amenorrhoea
Systematic review	49 premenopausal women Data from 1 RCT	Amenorrhoea 6 months 13/19 (68%) with first generation 26/30 (87%) with second generation	OR 3.00 95% CI 0.72 to 12.53 P = 0.13		Not significant
Systematic review	2085 premenopausal women 11 RCTs in this analysis	Amenorrhoea 1 year 322/857 (38%) with first generation 459/1228 (37%) with second generation	OR 0.92 95% CI 0.62 to 1.37 P = 0.70		Not significant
Systematic review	701 premenopausal women 3 RCTs in this analysis	Amenorrhoea 2 years 110/308 (35.7%) with first generation 143/393 (36.4%) with second generation	OR 0.94 95% CI 0.58 to 1.51 P = 0.79		Not significant
Systematic review	672 premenopausal women 4 RCTs in this analysis	Amenorrhoea 2 to 5 years 147/304 (43%) with first generation 194/368 (53%) with second generation	OR 1.30 95% CI 0.61 to 2.79 P = 0.49		Not significant