Table 1.
Peripheral blood counts
| Untreated
|
Doxycycline 7 days
|
|||
|---|---|---|---|---|
| Littermate controls (n = 12) | CMV-rtTA; TRE-GFP-shBclxL (n = 5) | Littermate controls (n = 24) | CMV-rtTA; TRE-GFP-shBclxL (n = 8) | |
| Erythrocytes (× 106 lL−1) | 11.2 ± 0.1 | 11.5 ± 0.2 | 11.1 ± 0.1 | 10.9 ± 0.2 |
| Hematocrit (%) | 51.9 ± 0.6 | 53.4 ± 0.4 | 52.3 ± 0.5 | 52.2 ± 0.8 |
| MCV (femtoliters) | 46.3 ± 0.5 | 46.5 ± 0.8 | 47.3 ± 0.3 | 48.0 ± 0.3 |
| Leukocytes (× 103 lL−1) | 9.8 ± 0.4 | 9.2 ± 0.8 | 9.7 ± 0.4 | 6.7 ± 0.4* |
| Neutrophils (× 103 lL−1) | 1.3 ± 0.2 | 1.0 ± 0.1 | 1.4 ± 0.2 | 0.9 ± 0.1 |
| Lymphocytes (× 103 lL−1) | 7.9 ± 0.3 | 7.6 ± 0.8 | 7.7 ± 0.3 | 5.2 ± 0.4† |
| Monocytes (× 103 lL−1) | 0.2 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 |
| Platelets (× 103 lL−1) | 1364 ± 51 | 1258 ± 44 | 1273 ± 63 | 68 ± 16‡ |
| MPV (femtoliters) | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 11.3 ± 0.6¶ |
All mice were bled between 6 and 14 weeks of age. Littermate controls include wild type, CMV-rtTA single transgenic and TRE-GFP-shBclxL single transgenic mice.
MCV, mean corpuscular volume; MPV, mean platelet volume.
*
P < 0.001 compared with treated littermate controls (t-test).
†
P < 0.001 compared with treated littermate controls (t-test).
‡
P < 10−11 compared with treated littermate controls (t-test).
¶
P < 10−10 compared with treated littermate controls (t-test).