Figure 12.

T-Type Ca²⁺ channel antagonist 8 and ML218 produce a dose-dependent reversal of haloperidol (0.75 mg/kg, i.p.)-induced catalepsy in rats. (A) For comparison, the effects of increasing dose of 8 (i.p.) were compared to a top dose (56.6 mg/kg p.o.) of a previously published A_2A antagonist from Neurocrine. (B) Comparison of the effects of increasing dose of ML218 (p.o.) to the Neurocrine A_2A antagonist at 56.6 mg/kg (p.o.). Catalepsy was measured as the latency to withdraw the forepaws from a horizontal bar with a cutoff of 30 s. Bar graphs represent the means ± SEM of either 6–10 rats/treatment group (*p < 0.05 versus the vehicle control group by Dunnett’s test).