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. 2011 Oct 17;2(12):730–742. doi: 10.1021/cn200090z

Figure 9.

Figure 9

ML218 inhibits T-type calcium currents in STN neurons. (A) Averaged traces of T-currents (lower) elicited by a voltage clamp protocol (upper) in control (a) and after application of 3uM ML218 (b) in a voltage clamp experiment. (B) Time course of T-current amplitude before and after application of 3 uM ML218 from the same cell as in (A). (a) and (b) indicate the time points at which averaged traces were taken. (C) Bar graph summarizes group data showing ML218 inhibits T-currents in STN neurons (45.1 ± 5.1% of the control value, n = 7, **p < 0.005). Note that the inhibition persists 20 min after washout of ML218.