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. 2011 Dec 22;287(8):5542–5553. doi: 10.1074/jbc.M111.314716

FIGURE 2.

FIGURE 2.

Leukocytosis induced by differently structured heparins (heparinoids). A, structure of heparinoids involved in this study. Representative disaccharide units of unfractionated heparin (Hep), N-desulfated and N-acetylated heparin (N-des), 2-O/3-O-desulfated heparin (2/3-des), N-/2-O/3-O-desulfated heparin (N/2/3-des), 6-O-desulfated heparin (6-des), and carboxyl-reduced heparin (CR-hep). B and D, heparinoid-induced elevation of leukocytes in blood was assessed for leukocytosis (B), lymphocytosis (C), and neutrophilia (D). The data were summarized from three sets of experiments with 8–12 mice per group. Each bar represents the average value ± S.E. The statistical analysis was carried out by paired Student's t test in comparison with saline treatment. WBC, white blood cells.