FIGURE 5.

Heparin-induced leukocytosis depends on blockade of P- and L-selectin function. Mice deficient in selectin (L^−/−, P^−/−, and PL^−/−) or selectin ligand (FucT-IV/VII^−/−) were injected i.v. with heparin or saline and then analyzed for leukocytosis (A), lymphocytosis (B), and neutrophilia (C). The data were summarized from three sets of experiments with 6–10 mice per group. Each bar represents the average value ± S.E. The statistical analysis was carried out by paired Student's t test in comparison with saline treatment. WBC, white blood cells.