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. 2011 Dec 22;287(8):5562–5573. doi: 10.1074/jbc.M111.305359

FIGURE 2.

FIGURE 2.

Effect of FTY720 on β-cell mass of db/db mice. A, H&E staining of pancreas from the untreated and FTY720-treated mice after 6 and 9 weeks treatment (scale bar, 50 μm). B, insulin immunostaining (green fluorescence) of pancreas after 6 weeks FTY720 treatment (scale bar, 50 μm). C, stereological quantification of the insulin positive areas in the control and FTY720-treated db/db mice. Six consecutive paraffin sections (10 μm) from each pancreas (10 pancreases from the untreated and 9 from the FTY720-treatment db/db mice) were used for islet area measurements. *, p < 0.01.