FIGURE 2.
Structure and flexibility of the BLOC-1 molecule. A, negative stain electron micrograph of BLOC-1 molecules (white arrows) negatively stained with uranyl formate using the method of Valentine and Green (33). B, class averages of BLOC-1 molecules ordered from top left to bottom right according to their curvature. The averages were obtained in several iterations of multivariate statistical analysis and multi-reference classification. Statistics and dimensions of the class averages are summarized in Table 1.