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. 2011 Dec 20;287(8):6002–6013. doi: 10.1074/jbc.M111.310110

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Effects of intrathecal treatment with Cavβ₃-specific siRNA (5 μg per day for 3 days) on nociceptive and tactile withdrawal thresholds of hind paws in SNL rats. A, time course effects of control siRNA and Cavβ₃-specific siRNA on the nociceptive withdrawal threshold, tested with a noxious pressure stimulus, of hind paws ipsilateral and contralateral to SNL (n = 6 rats in each group). B, time course effects of control siRNA and Cavβ₃-specific siRNA on the tactile withdrawal threshold, measured with von Frey filaments, of hind paws ipsilateral and contralateral to SNL (n = 6 rats in each group). Note that Cavβ₃-specific siRNA, but not control siRNA, increased nociceptive and tactile withdrawal thresholds of hind paws ipsilateral to SNL. Ipsi, ipsilateral (nerve injury) side; Cont, contralateral (control) side. *, p < 0.05, compared with the base-line value in Cavβ₃-specific siRNA-treated group.