| Raltegravir |
HIV-1 integrase; antiviral for treatment of HIV-infected patients |
metnase; adjuvant therapy in cancer |
virtual screening supported by experiments |
pilot clinical trial for head and neck squamos cell carcinoma is on-going |
| Cyclobenzaprine |
not described; skeletal muscle relaxant |
mono-amine transporters and serotonin receptors; may cause serotonin syndrome |
virtual screening supported by experiments |
N/A |
| Benzbromarone |
xanthine oxidase; uricosuric for treatment of gout |
quorum sensing signaling pathway; antibacterial |
target-based screening of the Prestwick Chemical Library |
abandoned because it lacks patent in vivo activity |
| Mometasone Furoate |
glucocorticoid receptors; for treatment of seasonal allergy |
P-glycoprotein; adjuvant therapy in cancer |
target-based screening of the Prestwick Chemical Library |
abandoned because the target (P-gp) was proved to lack effectiveness in clinical trials for Zosuiquidar |
| Astemizole |
histamine H1 receptors; antihistamine for treatment of seasonal allergy |
inducer of autophagy; as adjuvant therapy in prostate cancer |
phenotypic screening of the Prestwick Chemical Library |
in vivo studies for prostate cancer are on-going |
| R-Naproxen |
cyclooxygenases; non-steroidal anti-inflammatory drug for short-term treatment of pain |
RAC and CDC42 GTPases; as adjuvant therapy in cancer |
target-based screening of the Prestwick Chemical Library |
abandoned in favor of ketorolac |
| Ketorolac |
cyclooxygenases; non-steroidal anti-inflammatory drug for short-term treatment of pain |
RAC and CDC42 GTPases; as adjuvant therapy in cancer |
virtual screening based on Naproxen |
pilot clinical trial for ovarian cancer, to evaluate peritoneal distribution |
| Tolfenamic acid |
cyclooxygenases; non-steroidal anti-inflammatory drug for short-term treatment of pain |
inhibitor of hantavirus/DAF binding; antiviral against Sin Nombre virus |
phenotypic screening |
medicinal chemistry optimization under consideration |
| Phenothiazines |
prototype for neuroleptic drugs; antipsychotics for the management of schizophrenia |
VLA-4; anti-adhesion inhibitors against inflammation and cancer |
target-based screening of the Prestwick Chemical Library |
in vivo studies for hematologic malignancies are on-going |
| Methylergonovine maleate |
oxytocic; for treatment of post-partum uterine hemmorhage |
Bcl-2 family proteins; anti-apoptotic as adjuvant therapy in cancer |
target-based screening of the Prestwick Chemical Library |
abandoned because it has other potent in vivo activity |
| Beta-adrenergic receptor drugs |
beta-2 adrenergic receptor agonists are used for the therapeutic management of asthma |
non-cannonical G-protein coupled receptor ligands |
target-based screening of the Prestwick Chemical Library |
in vitro biological tests are on-going |
