Figure 3. Lp-PLA2 mRNA and protein are upregulated in human foam-like cells in vitro.
Lp-PLA2 mRNA was significantly greater (P<0.01) in foam cells than in mature macrophages (A). Similarly, cell-associated (P=0.05) and secreted (P=0.008) Lp-PLA2 protein levels were higher in foam cells than in macrophages † (B). (ANOVA and Bonferroni post-hoc tests). † As monocytes were grown in suspension, protein levels were measured in monocyte cell lysates but could not be measured in media.