Table 3.
Association of SNPs in (A) PLA2G7 but not in (B) CRP with Coronary Artery Calcification.
| (A) | *SIRCA&PAMSYN (n=1279) | *PDHS (n=782) | Meta-analysis (n=2061) | |||||
|---|---|---|---|---|---|---|---|---|
| †PLA2G7 SNP (Allele: Minor/Major) | Type of SNP | MAF | Beta | P | Beta | P | Z | P |
| rs1421378 (G/A) | Upstream | 0.41 | 0.31 | 9.8E-05 | 0.05 | 0.65 | 3.35 | 8.1E-04 |
| rs2216465 (C/G) | Intronic | 0.34 | 0.29 | 3.9E-04 | 0.05 | 0.67 | 3.06 | 0.002 |
| rs12528807 (C/A) | Intronic | 0.08 | 0.39 | 0.004 | 0.40 | 0.07 | 3.36 | 7.7E-04 |
| rs9349373 (A/G) | Upstream | 0.20 | 0.26 | 0.008 | 0.22 | 0.13 | 3.04 | 0.002 |
| rs10948300 (T/A) | Intronic | 0.21 | 0.24 | 0.013 | 0.32 | 0.02 | 3.36 | 7.8E-04 |
| rs1805017 (A/G) | Non-synonymous Coding | 0.26 | 0.22 | 0.014 | 0.09 | 0.49 | 2.37 | 0.018 |
| rs3799863 (A/T) | Intronic | 0.05 | 0.46 | 0.016 | −0.23 | 0.39 | 1.37 | 0.17 |
| rs16874967 (A/G) | Intronic | 0.06 | 0.39 | 0.02 | −0.14 | 0.56 | 1.41 | 0.16 |
| rs1805018 (G/A) | Non-synonymous Coding | 0.06 | 0.39 | 0.02 | −0.14 | 0.56 | 1.41 | 0.16 |
| rs12195701 (A/G) | Intronic | 0.21 | 0.21 | 0.03 | 0.26 | 0.07 | 2.85 | 0.004 |
| rs1421368 (G/A) | Intronic | 0.10 | −0.27 | 0.04 | −0.17 | 0.37 | −2.16 | 0.03 |
| rs9472830 (A/G) | Intronic | 0.20 | −0.19 | 0.05 | −0.16 | 0.23 | −2.26 | 0.02 |
| rs1362931 (A/C) | Intronic | 0.20 | −0.19 | 0.05 | −0.16 | 0.23 | −2.25 | 0.02 |
| rs1421372 (A/G) | Intronic | 0.20 | −0.19 | 0.05 | −0.16 | 0.23 | −2.25 | 0.02 |
| rs3799861 (A/G) | Intronic | 0.20 | −0.19 | 0.05 | −0.16 | 0.23 | −2.25 | 0.02 |
| rs7756935 (C/A) | Intronic | 0.21 | −0.16 | 0.11 | −0.15 | 0.25 | −1.98 | 0.05 |
| rs1051931 (A/G) | Non-synonymous Coding | 0.21 | −0.16 | 0.11 | −0.16 | 0.23 | −2.01 | 0.04 |
| rs16874962 (A/G) | Intronic | 0.07 | 0.12 | 0.44 | 0.15 | 0.46 | 1.06 | 0.29 |
| rs17288905 (G/A) | Intronic | 0.084 | −0.04 | 0.76 | −0.02 | 0.94 | −0.29 | 0.77 |
| (B) | * SIRCA&PAMSyN (n=1279) | * PDHS (n=782) | Meta-analysis (n=2061) | |||||
|---|---|---|---|---|---|---|---|---|
| †CRP SNP (Allele: Minor/Major) | Type of SNP | MAF | Beta | P | Beta | P | Z | P |
| rs3093068 (G/C) | 3′ Downstream | 0.06 | −0.32 | 0.04 | −0.09 | 0.70 | −1.82 | 0.07 |
| rs3093059 (G/A) | 5′ Upstream | 0.07 | −0.31 | 0.06 | −0.11 | 0.65 | −1.78 | 0.07 |
| rs12068753 (A/T) | 5′ Upstream | 0.07 | −0.31 | 0.06 | −0.08 | 0.75 | −1.70 | 0.09 |
| rs12084589 (A/C) | 5′ Upstream | 0.07 | −0.31 | 0.06 | −0.05 | 0.83 | −1.63 | 0.10 |
| rs2808631 (G/A) | 3′ Downstream | 0.002 | −1.52 | 0.07 | 0.52 | 0.64 | −1.16 | 0.25 |
| rs1800947 (G/C) | Synonymous coding | 0.07 | 0.19 | 0.23 | 0.29 | 0.18 | 1.77 | 0.08 |
| rs2794521 (G/A) | 5′ Upstream | 0.25 | −0.11 | 0.23 | 0.01 | 0.93 | −0.90 | 0.37 |
| rs1130864 (A/G) | 3′UTR | 0.30 | 0.10 | 0.27 | −0.15 | 0.21 | 0.10 | 0.92 |
| rs2808634 (A/G) | 5′ Upstream | 0.27 | −0.09 | 0.30 | 0.00 | 0.98 | −0.84 | 0.40 |
| rs3093071 (A/C) | 3′ Downstream | 0.01 | −0.23 | 0.54 | −0.21 | 0.67 | −0.75 | 0.45 |
| rs3093066 (A/C) | 3′UTR | 0.001 | −0.57 | 0.57 | −1.52 | 0.33 | −1.04 | 0.30 |
| rs3093069 (C/A) | 3′UTR | 0.001 | −0.57 | 0.57 | 1.54 | 0.49 | −0.01 | 0.99 |
| rs1205 (A/G) | 3′ Downstream | 0.34 | 0.04 | 0.65 | 0.16 | 0.17 | 1.20 | 0.23 |
| rs3093070 (C/A) | 5′ Upstream | 0.02 | −0.13 | 0.69 | −0.67 | 0.56 | −0.22 | 0.50 |
| rs3091244 (A/G) | 3′ Downstream | 0.37 | −0.89 | 0.99 | 0.00 | 0.15 | −0.17 | 0.37 |
*
PAMSyN=the Philadelphia Area Metabolic Syndrome Network; SIRCA=the Study of Inherited Risk of Coronary Atherosclerosis; PDHS=the Penn Diabetes Heart Study. MAF=minor allele frequency.
†
For all analyses, the effect allele corresponds to the minor allele. MAF=minor allele frequency.