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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Clin Perinatol. 2012 Jan 11;39(1):83–98. doi: 10.1016/j.clp.2011.12.008

Table 1.

Pediatric Antifungal Dosing14–25

Drug Formulation Infants
(31 days–2 years)		 Neonates
(0–30 days)		 FDA label
Polyenes
Amphotericin B
deoxycholate		 IV 1 mg/kg/day 1 mg/kg/day children and adults
ABLC IV unknown unknown >16 months
ABCD IV unknown unknown children and adults
L-Amphotericin B IV 5 mg/kg/day 5 mg/kg/day ≥1 month
Nucleoside analogs
5-Flucytosine PO 50–150 mg/kg/day
q 6 hr		 50–150 mg/kg/day
q 6 hr		 adults
Triazoles
Fluconazole IV, PO 12 mg/kg/day
(25 mg/kg/loading dose)		 12 mg/kg/day
(25 mg/kg load)		 ≥6 months
Voriconazole IV, PO unknown unknown ≥12 years
Posaconazole PO unknown unknown ≥13 years
Echinocandins
Caspofungin IV 50 mg/m2/day 25 mg/m2/day >3 months
Micafungin IV 10 mg/kg/day 10 mg/kg/day adults
Anidulafungin IV 1.5 mg/kg/day
(3 mg/kg/loading dose)		 1.5 mg/kg/day
(3 mg/kg/load)		 adults

IV: intravenous; PO: oral